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Biosil: The Science of Health and Beauty
Stimulating Collagen:
Your Body's Health and Beauty Protein
Collagen has been called the most important building block in the human body. It comprises over a
third of your body's proteins. It makes up 75% of your skin. It is the sole supporting structure for your
bones, joints, and vital organs. In humans, collagen production begins to diminish by age 18. But
there's good news. Biosil is the first clinically proven, orally active collagen generator shown to help
reduce fine lines and wrinkles, strengthen and thicken hair, strengthen nails, increase bone mineral
density and improve joints.
Biosil (ch-OSA): The Scientific Breakthrough in Collagen
It wasn't until the landmark creation of ch-OSA (choline-stabilized Ortho Silicic Acid) that a scientific
breakthrough to stimulate the body's own production of collagen would become a reality. For years,
scientists recognized that orthosilicic acid (OSA) had the potential to stimulate the production of
collagen. But there was a problem. OSA is highly unstable and converts to a form not well absorbed
by humans. Then after years of research and development, an elite team of international scientists
created and applied their "choline-stabilization" technology to OSA. Their patented innovation, known
as ch-OSA complex, became the first biologically stable and absorbable form of OSA. Suddenly, the
world had a scientifically-validated orally-active collagen generator. The historic discovery was hailed
the "breakthrough in the science of collagen." And it's now available to you in BioSil.
Clinically Tested - Safe and Effective
You'll be happy to know that Biosil has been the subject of the most rigorous testing procedure
known: the double blind, placebo-controlled university-conducted clinical trial. The gold standard,
preferred by U.S. government and employed by the pharmaceutical companies. The results were as
dramatic as they were statistically significant. Subjects taking Biosil showed a marked improvement
in the appearance of photo-damaged skin, enhancement in strength of hair and nails, and an
increase in bone mineral density (BMD). Best of all, Biosil was found to be safe.
Biosil: Improving Your Life - Starting Today!
Your Skin - By stimulating collagen in your skin, Biosil helps reduce fine lines and wrinkles, increase
elasticity and promote hydration. Support of these benefits emerged in a recent clinical trial in which
fifty women between 40 and 65 years old with symptoms of aging facial skin were divided into two
groups, one taking a placebo and the other taking 10 mg Biosil per day for the 20-week period (Barel
et al., 2005). No other anti-aging treatment was followed. Researchers examined changes in skin
roughness, elasticity and structure. Brittleness of the nails and hair was also measured. The results
demonstrated that subjects taking Biosil experienced a 19% reduction in fine lines, wrinkles, and
skin roughness. Similarly, the skin of the Biosil group exhibited improved elasticity compared with
those taking the placebo. Both hair and nails showed less brittleness after 20 weeks of
supplementation with Biosil. All these results showed statistically significant improvements in the
Biosil group compared with baseline or placebo group.
Your Hair - Biosil helps your hair grow thicker. The ch-OSA in Biosil, has been clinically shown to
significantly increase the diameter of each hair shaft - adding fullness and body to your hair. In
addition, Biosil helps make your hair stronger, more elastic, and more break resistant (Wickett, et al.,
2007).
Your Nails - Biosil has been clinically shown to strengthen your nails, making them more break
resistant (Bare, et al., 2005). The Biosil nail phenomena has given birth to a new expression:
"Unbreakable Beauty."
Your Bone Mineral Density - This may be the most important finding about Biosil. It concerns your
bone mineral density in both full-length thigh bone and hip region of thigh bone. In a clinical trial
(Spector, et al., 2005), subjects were divided into four groups: Biosil (3 mg, 6 mg, or 12 mg) and
placebo. The Biosil groups took Biosil, calcium, and vitamin D. The placebo group took only calcium
and vitamin D. Placebo subjects lost 1.22% in bone mineral density at the hip region whereas the
Biosil subjects gained 0.78%. That's a significant difference of 2.00% - twice the clinically relevant
threshold.
New Studies About Bone Support - Reffitt and Powell (2003) showed that orthosilicic acid (OSA),
stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells
in vitro. These in vitro results suggests that OSA may have a stimulatory effect on actual bone
formation. The action of OSA is likely the formation of the bone matrix.
Your Joints - Collagen is essential for maintaining articular cartilage in your joints, as well as
ensuring the integrity of your ligaments. Orthosilicic acid has been shown to stimulate collagen and
matrix synthesis, secondary to its stimulatory effects on osteoblasts and fibroblasts (Reffitt et al.,
2003). This data confirms the important role of orthosilicic acid for healthy bones and joints. And only
Biosil provides you with the patented choline-stabilized for of orthosilicic acid to help ensure effective
results.
Your Heart - Aorta and Other Arterial Tissue - Collagen plays a key role in the strength and integrity
of your tunica intima, the inner lining of your arterial tissue, strongly suggesting the cardiovascular
benefits of Biosil.
References
Barel, A., Calomme, M., Timchenko, A., et al (2005). Effect of oral intake of choline-stabilized orthosilicic acid on
skin, nails and hair in women with photo-damaged skin. Archives of Dermatological Research, 297, 147–153.
Birchall J.D., Exley C. et al, (1989) Acute toxicity of aluminum to fish eliminated in silicon-rich acid waters. Nature,
338, 146-148.
Calomme, M. R. and Vanden Berghe, D. A. (1997). Supplementation of calves with stabilized orthosilicic acid.
Effect on the Si, Ca, Mg, and P concentrations in serum and the collagen concentration in skin and cartilage.
Biological Trace Element Research, 56, 153–65.
Calomme, M.R., et al (1998). Comparative bioavailability study of silicon supplements in healthy subjects. Journal of
Parenteral and Enteral Nutrition, Vol. 22, S12.
Calomme, M.R., et al(2002). Effect of choline-stabilized orthosilicic acid on bone density in chicks. Calciium Tissue
International, 70, 292.
Carlisle E.M. (1970) Silicon: a possible growth factor in bone calcification. Science, 167, 279-280. Carlisle E.M.
(1970) In vivo requirement for silicon in articular cartilage and connective tissue formation in the chick. Journal of
Nutrition, 106, 478-484.
Carlisle E.M. ( 1986) Silicon as an essential trace element in animal nutrition, in Silicon Biochemistry, CIBA
Foundation Symposium 121, John Wiley and Sons, New York, 123-139.
Carlisle E.M. and Curran M.J. (1987) Effort of dietary silicon and aluminum on silicon and aluminum levels in rat
brain. Alzheimer Disease and Associated Disorders, 1, 83-89.
Eisinger J. and Clairet D. (1993) Effetcs of silicon, fluoride, etidronate and magnesium on bone mineral density: a
retrospective study. Magnesium Research, 6, 247-249.
Frey K.S., Pottery G.D. et al., (1993) Plasma silicon and radiographic bone density in weaning quarter horses fed
sodium zeolite A. Equine Vet Science, 12, 292-296.
Hott M., de Pollak C. et al., (1993) Short-term effects or organic silicon on trabecular bone in mature
ovariectomized rats, Calcified Tissue International, 53, 174-179.
Jugdaohsingh R., Tucker K.L., et al., (2003) Silicon uptake is a major dietary determinant of bone mineral density
(BMD) in men and per-menopausal women of the Framingham Offspring Cohort. Bone, 32,S192.
Loeper J., Goy-Loeper J. et al., (1979) The antiatheromatous action of silicon. Atherosclerosis, 33, 397-408.
Reffitt, D. M., Powell, J. J. (2003). Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic
differentiation in human osteoblast-like cells in vitro. Bone, 32, 127–135.
Spector, T.D., Calomme M.R., et al., (2005). Effect on bone turnover and BMD of low dose oral silicon as an
adjunct to Calcium/Vitamin D3 in a randomized, placebo-controlled trial. 27th Annual Meeting American Society for
Bone and Mineral Research, Nashville, September 2005, abstract.
Wickett R.R., Kossmann E., Barel A.O. (2007) Effect of oral intake of choline-stabilized orthosilicic acid on hair
tensile strength and morphology in women with fine hair. Paper presented at: Fifth International Congress on Hair
Research, Vancouver, Canada, June 13-16 2007.
Stimulating Collagen:
Your Body's Health and Beauty Protein
Collagen has been called the most important building block in the human body. It comprises over a
third of your body's proteins. It makes up 75% of your skin. It is the sole supporting structure for your
bones, joints, and vital organs. In humans, collagen production begins to diminish by age 18. But
there's good news. Biosil is the first clinically proven, orally active collagen generator shown to help
reduce fine lines and wrinkles, strengthen and thicken hair, strengthen nails, increase bone mineral
density and improve joints.
Biosil (ch-OSA): The Scientific Breakthrough in Collagen
It wasn't until the landmark creation of ch-OSA (choline-stabilized Ortho Silicic Acid) that a scientific
breakthrough to stimulate the body's own production of collagen would become a reality. For years,
scientists recognized that orthosilicic acid (OSA) had the potential to stimulate the production of
collagen. But there was a problem. OSA is highly unstable and converts to a form not well absorbed
by humans. Then after years of research and development, an elite team of international scientists
created and applied their "choline-stabilization" technology to OSA. Their patented innovation, known
as ch-OSA complex, became the first biologically stable and absorbable form of OSA. Suddenly, the
world had a scientifically-validated orally-active collagen generator. The historic discovery was hailed
the "breakthrough in the science of collagen." And it's now available to you in BioSil.
Clinically Tested - Safe and Effective
You'll be happy to know that Biosil has been the subject of the most rigorous testing procedure
known: the double blind, placebo-controlled university-conducted clinical trial. The gold standard,
preferred by U.S. government and employed by the pharmaceutical companies. The results were as
dramatic as they were statistically significant. Subjects taking Biosil showed a marked improvement
in the appearance of photo-damaged skin, enhancement in strength of hair and nails, and an
increase in bone mineral density (BMD). Best of all, Biosil was found to be safe.
Biosil: Improving Your Life - Starting Today!
Your Skin - By stimulating collagen in your skin, Biosil helps reduce fine lines and wrinkles, increase
elasticity and promote hydration. Support of these benefits emerged in a recent clinical trial in which
fifty women between 40 and 65 years old with symptoms of aging facial skin were divided into two
groups, one taking a placebo and the other taking 10 mg Biosil per day for the 20-week period (Barel
et al., 2005). No other anti-aging treatment was followed. Researchers examined changes in skin
roughness, elasticity and structure. Brittleness of the nails and hair was also measured. The results
demonstrated that subjects taking Biosil experienced a 19% reduction in fine lines, wrinkles, and
skin roughness. Similarly, the skin of the Biosil group exhibited improved elasticity compared with
those taking the placebo. Both hair and nails showed less brittleness after 20 weeks of
supplementation with Biosil. All these results showed statistically significant improvements in the
Biosil group compared with baseline or placebo group.
Your Hair - Biosil helps your hair grow thicker. The ch-OSA in Biosil, has been clinically shown to
significantly increase the diameter of each hair shaft - adding fullness and body to your hair. In
addition, Biosil helps make your hair stronger, more elastic, and more break resistant (Wickett, et al.,
2007).
Your Nails - Biosil has been clinically shown to strengthen your nails, making them more break
resistant (Bare, et al., 2005). The Biosil nail phenomena has given birth to a new expression:
"Unbreakable Beauty."
Your Bone Mineral Density - This may be the most important finding about Biosil. It concerns your
bone mineral density in both full-length thigh bone and hip region of thigh bone. In a clinical trial
(Spector, et al., 2005), subjects were divided into four groups: Biosil (3 mg, 6 mg, or 12 mg) and
placebo. The Biosil groups took Biosil, calcium, and vitamin D. The placebo group took only calcium
and vitamin D. Placebo subjects lost 1.22% in bone mineral density at the hip region whereas the
Biosil subjects gained 0.78%. That's a significant difference of 2.00% - twice the clinically relevant
threshold.
New Studies About Bone Support - Reffitt and Powell (2003) showed that orthosilicic acid (OSA),
stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells
in vitro. These in vitro results suggests that OSA may have a stimulatory effect on actual bone
formation. The action of OSA is likely the formation of the bone matrix.
Your Joints - Collagen is essential for maintaining articular cartilage in your joints, as well as
ensuring the integrity of your ligaments. Orthosilicic acid has been shown to stimulate collagen and
matrix synthesis, secondary to its stimulatory effects on osteoblasts and fibroblasts (Reffitt et al.,
2003). This data confirms the important role of orthosilicic acid for healthy bones and joints. And only
Biosil provides you with the patented choline-stabilized for of orthosilicic acid to help ensure effective
results.
Your Heart - Aorta and Other Arterial Tissue - Collagen plays a key role in the strength and integrity
of your tunica intima, the inner lining of your arterial tissue, strongly suggesting the cardiovascular
benefits of Biosil.
References
Barel, A., Calomme, M., Timchenko, A., et al (2005). Effect of oral intake of choline-stabilized orthosilicic acid on
skin, nails and hair in women with photo-damaged skin. Archives of Dermatological Research, 297, 147–153.
Birchall J.D., Exley C. et al, (1989) Acute toxicity of aluminum to fish eliminated in silicon-rich acid waters. Nature,
338, 146-148.
Calomme, M. R. and Vanden Berghe, D. A. (1997). Supplementation of calves with stabilized orthosilicic acid.
Effect on the Si, Ca, Mg, and P concentrations in serum and the collagen concentration in skin and cartilage.
Biological Trace Element Research, 56, 153–65.
Calomme, M.R., et al (1998). Comparative bioavailability study of silicon supplements in healthy subjects. Journal of
Parenteral and Enteral Nutrition, Vol. 22, S12.
Calomme, M.R., et al(2002). Effect of choline-stabilized orthosilicic acid on bone density in chicks. Calciium Tissue
International, 70, 292.
Carlisle E.M. (1970) Silicon: a possible growth factor in bone calcification. Science, 167, 279-280. Carlisle E.M.
(1970) In vivo requirement for silicon in articular cartilage and connective tissue formation in the chick. Journal of
Nutrition, 106, 478-484.
Carlisle E.M. ( 1986) Silicon as an essential trace element in animal nutrition, in Silicon Biochemistry, CIBA
Foundation Symposium 121, John Wiley and Sons, New York, 123-139.
Carlisle E.M. and Curran M.J. (1987) Effort of dietary silicon and aluminum on silicon and aluminum levels in rat
brain. Alzheimer Disease and Associated Disorders, 1, 83-89.
Eisinger J. and Clairet D. (1993) Effetcs of silicon, fluoride, etidronate and magnesium on bone mineral density: a
retrospective study. Magnesium Research, 6, 247-249.
Frey K.S., Pottery G.D. et al., (1993) Plasma silicon and radiographic bone density in weaning quarter horses fed
sodium zeolite A. Equine Vet Science, 12, 292-296.
Hott M., de Pollak C. et al., (1993) Short-term effects or organic silicon on trabecular bone in mature
ovariectomized rats, Calcified Tissue International, 53, 174-179.
Jugdaohsingh R., Tucker K.L., et al., (2003) Silicon uptake is a major dietary determinant of bone mineral density
(BMD) in men and per-menopausal women of the Framingham Offspring Cohort. Bone, 32,S192.
Loeper J., Goy-Loeper J. et al., (1979) The antiatheromatous action of silicon. Atherosclerosis, 33, 397-408.
Reffitt, D. M., Powell, J. J. (2003). Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic
differentiation in human osteoblast-like cells in vitro. Bone, 32, 127–135.
Spector, T.D., Calomme M.R., et al., (2005). Effect on bone turnover and BMD of low dose oral silicon as an
adjunct to Calcium/Vitamin D3 in a randomized, placebo-controlled trial. 27th Annual Meeting American Society for
Bone and Mineral Research, Nashville, September 2005, abstract.
Wickett R.R., Kossmann E., Barel A.O. (2007) Effect of oral intake of choline-stabilized orthosilicic acid on hair
tensile strength and morphology in women with fine hair. Paper presented at: Fifth International Congress on Hair
Research, Vancouver, Canada, June 13-16 2007.
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